Avföringstransplantation lindrade symtom på Alzheimers i en studie på transgena APP / PS1-möss.
Alzheimers är associerat till en onormal mikrobiota i tarmen. Men ännu är väldigt lite är känt kring avföringstransplantation vid Alzheimers. Här utvärderades effekten på möss.
Kognitiv förmåga, avlagringar av amyloidplack och tau i hjärnan, synaptisk plastisitet samt neuroinflammation bedömdes. Tarmmikrobiota och dess metaboliter kortkedjiga fettsyror (SCFA) analyserades.
Resultat visade att avföringstransplantation förbättrade den kognitiva förmågan och minskade utfällningen av amyloidplack i hjärnan. Dessa förbättringar åtföljdes av minskad fosforylering av tau-protein. Man observerade även en ökning av synaptisk plasticitet samt minskning av inflammation (COX-2- och CD11b-nivåer) efter avföringstransplantation.
Ur studien:
“Alzheimer’s disease (AD) is the most common dementia in the elderly. Treatment for AD is still a difficult task in clinic. AD is associated with abnormal gut microbiota. However, little is known about the role of fecal microbiota transplantation (FMT) in AD. Here, we evaluated the efficacy of FMT for the treatment of AD. We used an APPswe/PS1dE9 transgenic (Tg) mouse model. Cognitive deficits, brain deposits of amyloid-β (Aβ) and phosphorylation of tau, synaptic plasticity as well as neuroinflammation were assessed. Gut microbiota and its metabolites short-chain fatty acids (SCFAs) were analyzed by 16S rRNA sequencing and 1H nuclear magnetic resonance (NMR). Our results showed that FMT treatment could improve cognitive deficits and reduce the brain deposition of amyloid-β (Aβ) in APPswe/PS1dE9 transgenic (Tg) mice. These improvements were accompanied by decreased phosphorylation of tau protein and the levels of Aβ40 and Aβ42. We observed an increases in synaptic plasticity in the Tg mice, showing that postsynaptic density protein 95 (PSD-95) and synapsin I expression were increased after FMT. We also observed the decrease of COX-2 and CD11b levels in Tg mice after FMT. We also found that FMT treatment reversed the changes of gut microbiota and SCFAs. Thus, FMT may be a potential therapeutic strategy for AD.”
Mer via https://4health.se/tag/microbiome och https://4health.se/tag/demens
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