fett

I en japansk studie fick 20 personer med Alzheimers sjukdom äta antingen en ketogen kost med MCT-fett (medellånga triglycerider) eller vanlig kost. De som ätit MCT-ketogen kost uppvisade efter tolv veckor signifikanta förbättringar i minnestester jämfört med gruppen som ätit som vanligt.

Forskarna konstaterar att konstant konsumtion av den ketogena kosten förbättrar kognitionen hos Alzheimers-patienter, och att dessa förbättringar troligen kan härledas från den gynnsamma effekten på insulinresistensen.

Ur studien:
“Highlights
• Single intake of ketogenic formula increases the concentration of ketone bodies.

• Chronic consumption of the ketogenic formula ameliorate the cognition of AD patients.

• These improvements may be derived from the beneficial effect on insulin resistance.

Abstract
Clinical and animal studies suggested that a medium-chain triglyceride (MCT)-based ketogenic diet provides an alternative energy substrate to the brain and has neuroprotective effects, but the clinical evidence is still scarce. Here we examined the effect of an MCT-based ketogenic formula on cognitive function in patients with Alzheimer’s disease (AD). The subjects were 20 Japanese patients with mild-to-moderate AD (11 males, nine females, mean age 73.4 ± 6.0 years) who, on separate days, underwent neurocognitive tests 120 min after consuming 50 g of a ketogenic formula (Ketonformula®) containing 20 g of MCTs or an isocaloric placebo formula without MCTs. The patients then took 50 g of the ketogenic formula daily for up to 12 weeks, and underwent neurocognitive tests monthly. In the first trial, although the patients’ plasma levels of ketone bodies were successfully increased 120 min after the single intake of the ketogenic formula, there was no significant difference in any cognitive test results between the administrations of the ketogenic and placebo formulae. In the subsequent chronic intake trial of the ketogenic formula, 16 of the 20 patients completed the 12-week regimen. At 8 weeks after the trial’s start, the patients showed significant improvement in their immediate and delayed logical memory tests compared to their baseline scores, and at 12 weeks they showed significant improvements in the digit-symbol coding test and immediate logical memory test compared to the baseline. The chronic consumption of the ketogenic formula was therefore suggested to have positive effects on verbal memory and processing speed in patients with AD.”

Mer via https://4health.se/tag/demens

Lär dig mer om att förebygga demens i podcastavsnitten på temat – 215 och 33

https://4health.se/33-forebygga-bromsa-och-reversera-alzheimers-demenssjukdomar

https://4health.se/215-peter-wilhelmsson-radda-din-hjarna-fran-demens

https://www.sciencedirect.com/science/article/pii/S0304394018307304

• Försämrad glukosmetabolism i hjärnan, amyloida plack och celldöd är saker associerade med sjukdomspatologin i Alzheimers.
• Ketoner är en alternativ metabol väg till glukos i hjärnan.
• Ketogen kost reducerar sannolikt amyloidplack och kan minska deras neurotoxicitet.
• Modern kost med högt innehåll av kolhydrater kan bidra till Alzheimers.
• Den ketogena kosten (inklusive kolhydratrestriktion) kan vara användbar vid hanteringen av Alzheimers sjukdom.

Har skrivit och pratat om ketoner och dess effekt i Alzheimers sjukdom en hel del. Lyssna bl.a. på avsnitt 33  https://4health.se/33-forebygga-bromsa-och-reversera-alzheimers-demenssjukdomar samt avsnitt 12, och sök här på sidan eller använd taggen demens https://4health.se/tag/demens

Se även länken till en längre artikel i Health Impact News nedan

“The prevalence of Alzheimer’s disease, a chronic neurodegenerative condition, is increasing as is the need for effective treatments and preventions. The underlying pathology of Alzheimer’s is not yet fully understood, so existing research has focused on understanding the prominent features of the disease. These include amyloid plaques, which accumulate in the brains of those with Alzheimer’s disease; impaired glucose metabolism; and neuronal cell death. Emerging evidence suggests that a low-carbohydrate, high-fat ketogenic diet may help to mitigate the damage associated with these pathologies. The ketogenic diet could alleviate the effects of impaired glucose metabolism by providing ketones as a supplementary energy source. In addition, this diet may help to reduce the accumulation of amyloid plaques while reversing amyloid β toxicity. Research has begun to identify early underlying mechanisms in Alzheimer’s disease that could be targeted by new prevention strategies. Glycation of the ApoE protein leads to impaired transportation of important lipids, including cholesterol, to the brain, resulting in lipid deficiencies that could explain progression to the later pathologies of the disease. In this review, we hypothesize that the ketogenic diet could be an effective treatment and prevention for Alzheimer’s disease, but both ketone production and carbohydrate restriction may be needed to achieve this.”

https://www.sciencedirect.com/science/article/pii/S0899900718302764

http://healthimpactnews.com/2019/research-shows-high-fat-low-carb-diet-with-coconut-oil-can-prevent-or-cure-alzheimers/