Bikarbonat mot inflammation och autoimmun sjukdom

Både i råttor och människor som dricker bikarbonat upplöst i vatten mellan måltider, verkar dels produktionen av magsyra öka för att smälta nästa måltid. Och dessutom verkar kroppen börja signalera att immunförsvaret inte behöver öka sin inflammationsrespons. Det är som om kroppen förstår att det troligen är mat det handlar om, inte några farliga inkräktande mikrober.

Efter två veckor med bikarbonat skiftade fördelningen av makrofager mer mot de av typen M1 som minskar inflammation, och bort från typ M2, vilka ökar inflammation. Dessutom ökade produktionen av Treg-celler, vilket också kan dämpa inflammation.

På råttor testades bikarbonat vid njurfunktion. Njurarna har svårt att reglera pH med nedsatt njurfunktion, och detta kan avhjälpas något med tillskott av bikarbonat.

”A daily dose of baking soda may help reduce the destructive inflammation of autoimmune diseases like rheumatoid arthritis, scientists say. They have some of the first evidence of how the cheap, over-the-counter antacid can encourage our spleen to promote instead an anti-inflammatory environment that could be therapeutic in the face of inflammatory disease”

”They have shown that when rats or healthy people drink a solution of baking soda, or sodium bicarbonate, it becomes a trigger for the stomach to make more acid to digest the next meal and for little-studied mesothelial cells sitting on the spleen to tell the fist-sized organ that there’s no need to mount a protective immune response.”

”Mesothelial cells line body cavities, like the one that contains our digestive tract, and they also cover the exterior of our organs to quite literally keep them from rubbing together. About a decade ago, it was found that these cells also provide another level of protection. They have little fingers, called microvilli, that sense the environment, and warn the organs they cover that there is an invader and an immune response is needed.”

”Drinking baking soda, the MCG scientists think, tells the spleen — which is part of the immune system, acts like a big blood filter and is where some white blood cells, like macrophages, are stored — to go easy on the immune response. “Certainly drinking bicarbonate affects the spleen and we think it’s through the mesothelial cells,” ”

”The conversation, which occurs with the help of the chemical messenger acetylcholine, appears to promote a landscape that shifts against inflammation”

”after drinking water with baking soda for two weeks, the population of immune cells called macrophages, shifted from primarily those that promote inflammation, called M1, to those that reduce it, called M2. ”

”Clinical trials have shown that a daily dose of baking soda can not only reduce acidity but actually slow progression of the kidney disease, and it’s now a therapy offered to patients.”

”The shifting landscape, he says, is likely due to increased conversion of some of the proinflammatory cells to anti-inflammatory ones coupled with actual production of more anti-inflammatory macrophages. The scientists also saw a shift in other immune cell types, like more regulatory T cells, which generally drive down the immune response and help keep the immune system from attacking our own tissues. That anti-inflammatory shift was sustained for at least four hours in humans and three days in rats.”

”The shift ties back to the mesothelial cells and their conversations with our spleen with the help of acetylcholine. Part of the new information about mesothelial cells is that they are neuron-like”

“We think the cholinergic (acetylcholine) signals that we know mediate this anti-inflammatory response aren’t coming directly from the vagal nerve innervating the spleen, but from the mesothelial cells that form these connections to the spleen,”

“It’s potentially a really safe way to treat inflammatory disease.”

Tänk dock på att bikarbonat också kan påverka din matsmältning negativt eftersom det kan göra dig för basisk i magsäcken. Magsäcken måste ju vara sur (Läs och lyssna tidigare, bl.a. på : ) Därför bör du inte överdriva och dessutom ta det så långt från måltid som möjligt.

Tidigare om bikarbonat: https://4health.se/?s=bikarbonat

https://www.sciencedaily.com/releases/2018/04/180425093745.htm